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Edinburgh Uni Spin-out Raises £1m for Breakthrough ‘Liquid Biopsy’ Tech

Ross Kelly

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BioCaptiva

The seed funding will enable BioCaptiva to carry out its first trials to prove its technology is safe for use.

A Scottish bio-tech company has raised over £1 million in seed funding to help develop a ground-breaking “liquid biopsy” device.

BioCaptiva, a spin-out from the University of Edinburgh, says its novel biopsy device could revolutionise the early diagnosis and monitoring of cancers.

The firm raised the £1-million investment from Edinburgh-based business angel investment syndicate, Archangels, as well as Scottish Enterprise.

To prepare the company for this next stage in its development, BioCaptiva has also appointed Dr Frank Armstrong FRCPE as non-executive chairman and Dr Stephen Little as a non-executive director.

BioCaptiva’s medical device captures cfDNA (circulating free DNA) from the blood of patients in much greater quantities than the current standard of a single blood draw can, overcoming a significant current limitation of cancer liquid biopsy testing.

Named BioCollector, it works alongside a standard apheresis machine, filtering cfDNA from the patient’s blood system.

The BioCollector is based on a decade of research at the University of Edinburgh, led by Professor Tim Aitman, Director of the Centre for Genomic and Experimental Medicine, and Professor Mark Bradley of the University’s School of Chemistry.

Both researchers are co-founders and directors of the new company.

Prototypes indicate the potential to detect early-stage cancers in patients without the need for a surgical biopsy and promising new approaches for monitoring and detecting disease recurrence which is not currently possible. This should mean it is possible to gain deeper insights into tumour biology resulting in better patient outcomes.

The seed investment will enable BioCaptiva to in-license the technology and carry out its first trials to prove its safe use in humans. BioCaptiva has been launched with the support of Edinburgh Innovations, the University of Edinburgh’s commercialisation service.

Should the technology prove successful, BioCaptiva plans to scale up its technology ahead of regulatory clinical trials, scheduled for completion during 2024.

Jeremy Wheeler, CEO of BioCaptiva, commented: “The BioCollector is a disruptive technology which will be transformational for liquid biopsy testing.

“We are confident that this platform technology can make a significant impact in this important area and, ultimately, enable cancers to be detected more quickly and accurately, enabling patients to receive precision cancer treatment as early as possible.”


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Dr Sarah Hardy, Director, Head of New Investments at Archangels, added: “BioCaptiva has the potential to provide pharma companies and clinicians with high levels of cfDNA from individual patients that could revolutionise the way some cancers are detected.

“This has the potential to vastly increase the sensitivity and applicability of liquid biopsy for detection of cancerous tumours which are often diagnosed too late to enable specific treatment options to improve outcomes.”

Professor Tim Aitman, Director, Centre for Genomic and Experimental Medicine, University of Edinburgh, said: “I’m delighted that after several years of work with colleagues in Edinburgh, we will now progress towards first-in-human trials. BioCollector will provide a step change in the capabilities of liquid biopsy for cancer detection and diagnosis.

“We are excited to be moving our device into this market with its huge potential for advances in the care of patients with cancer.”

Ross Kelly

Staff Writer

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